p53 - Wikipedia
p53 plays a role in regulation or progression through the cell cycle, apoptosis, and genomic stability by means of several mechanisms: It can activate DNA repair proteins when DNA has …
Cell cycle regulation: p53-p21-RB signaling - Nature
Mar 31, 2022 · The tumor suppressor p53 can induce cell cycle arrest. Induction of p53 leads to transcriptional downregulation of many cell cycle genes. The cyclin-dependent kinase inhibitor...
The multiple mechanisms that regulate p53 activity and cell fate
Mar 1, 2019 · Following DNA damage, p53 upregulates the expression of genes involved in both cell cycle arrest and DNA repair (leading to cell survival) and apoptosis (leading to cell death).
Tumor Suppressor p53: Biology, Signaling Pathways, and …
P53 can also control the cell cycle through transcriptional regulation and direct interaction with PCNA and 14-3-3σ, thereby inhibiting DNA replication and G2/M arrest, respectively [100, …
The Regulation of p53 Growth Suppression - Madame Curie …
The p53 tumor suppressor protein plays a key role in the regulation of the cell cycle and cell death. The p53 protein is also involved in cell differentiation, DNA repair, senescence and …
The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor ...
This review focuses on the cell-cycle arrest and apoptosis functions of p53, their roles in tumor suppression, and the regulation of cell fate decision after p53 activation. p53 most notably …
Targeting p53 pathways: mechanisms, structures and advances in …
Mar 1, 2023 · The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and genomic stability, …
p53: A tale of complexity and context - Cell Press
Mar 28, 2024 · Indeed, p53 emerged as a protein of great versatility 6 that can regulate literally hundreds of genes whose products are greatly varied and are matched by a multitude of …
p53 on the crossroad between regeneration and cancer - PMC
p53 is termed the ‘guardian of the genome' 27 because of its profound role in preservation of cell genomic fidelity. Following exposure to cellular insults, p53 activity may lead to dual outcomes, …
The p53 network: cellular and systemic DNA damage ... - Cell Press
Mar 25, 2022 · The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most frequently mutated gene in human cancers. p53 plays a central role in responding …