Cell cycle regulation: p53-p21-RB signaling - Nature
Mar 31, 2022 · Facts. The tumor suppressor p53 can induce cell cycle arrest. Induction of p53 leads to transcriptional downregulation of many cell cycle genes. The cyclin-dependent kinase inhibitor...
Cell cycle regulation: p53-p21-RB signaling - PubMed
Following activation of p53, for example by viral infection or induction of DNA damage, p21 expression is upregulated. High levels of p21 then result in RB-E2F complex formation and downregulation of a large number of cell cycle genes. Thus, p53-dependent transcriptional repression is indirect.
p53-p21-RB signaling pathway. Following activation of p53, for example by viral infection or induction of DNA damage, p21 expression is upregulated.
The RB and p53 pathways in cancer - Cell Press
Jul 16, 2002 · Among the genes induced by p53 are the Cdk inhibitor p21 Cip1, many genes encoding proapoptotic proteins, and the p53 negative regulator Mdm2 (Hdm2 in humans) that plays a role in terminating the p53 response.
Tumor Suppressor p53: Biology, Signaling Pathways, and …
Through the interaction of CDK’s, p21 inhibits the phosphorylation of Rb which then remains bound to E2Fs preventing the transcription necessary for cell-cycle progression.
Targeting p53 pathways: mechanisms, structures and advances in …
Mar 1, 2023 · The gene encoding p21 (CDKN1A) is the first transcriptional target identified for p53. 55 p21 is a potent inhibitor of binding to cyclin-dependent kinases (CDKs), which inhibits cell cycle ...
Role of p53 in Regulating Radiation Responses - PMC - PubMed …
In breast cancer cells treated by 17-beta-estradiol after radiation injury, it does not affect p53 activation but decreases cyclin E binding to p21(waf1/cip1), and downstream Rb hyperphosphorylation persists due to functional p21(waf1/cip1) inactivation, resulting …
Cell cycle regulation: p53-p21-RB signaling - Semantic Scholar
DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation. It is shown that DREAM and RB are key factors in the p53 signaling pathway to downregulate a large number of cell-cycle genes and to arrest the cell cycle at the G1/S transition.
Differential regulation of p21 by p53 and Rb in cellular ... - PubMed
Finally, we provide evidence that the retinoblastoma gene product (Rb) is a negative regulator of p21 and a repressor of the cellular apoptotic process. Because p21 is regulated by p53 positively and by Rb negatively, p21 may be a link between p53 and Rb in determining cell fate after oxidative damage.
IRF3 activates RB to authorize cGAS-STING–induced ... - Science
Feb 28, 2024 · This research enhances our understanding of the p53-p21 Cip1/Waf1 and p16 INK4a-RB mechanisms in controlling senescence and broadens the scope of cGAS-STING signaling in the context of senescence-related diseases.
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