PC3 (PC-3) is a human prostate cancer cell line used in prostate cancer research and drug development. [1] PC3 cells are useful in investigating biochemical changes in advanced prostate cancer cells and in assessing their response to chemotherapeutic agents .

PC3 is a cell line characteristic of prostatic small cell carcinoma. Prostate 71:1668-1679(2011) PubMed= 22068913 ; DOI= 10.1073/pnas.1111840108 ; PMCID= PMC3219108

Various preclinical models have been developed to clarify the pathophysiology of prostate cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by DU-145, PC-3, and LNCaP cells, are useful tools to define mechanisms underlying tumorigenesis and …

PC3 cells do not express AR and PSA and their proliferation is independent of androgen, similar to SCNC. Adenocarcinoma cells and LNCaP cells are negative for neuroendocrine markers and stem cell-associated marker CD44 while SCNC and PC3 cells are positive.

PC-3M cells are metastasis-derived variant of PC3. Tumors from the prostate or lymph nodes were harvested after intraprostate growth, and cells were reinjected into the prostate. This cycle was repeated three to five times to yield cell lines PC-3M-Pro4, and PC-3M-LN4.

PC3 cells are a human prostate cancer cell line that was originally isolated from the bone marrow of a patient with advanced prostate cancer in 1979. PC-3 cells are commonly used as a model system for studying prostate cancer and evaluating potential therapies.

Prostatic small cell neuroendocrine carcinoma (SCNC) is a variant form of prostate cancer (PC). In contrast to adenocarcinoma, the tumor cells of SCNC do not form glands and are negative for AR and PSA.

The PC-3 cell line's attributes like androgen receptor non-responsiveness, high metastatic potential, and specific chromosomal aberrations make it an invaluable model for studying advanced prostate cancer mechanisms and testing new therapeutic strategies.

Excellent signal/background ratio and stable Luciferase expression make this cell line ideal for in vivo bioluminescence imaging of xenograft animal model to study human cancer and monitor activity of anti-cancer drug. It also can be used in cell-based assays for cancer research.

PC-3 cells are androgen-independent human advanced adenocarcinoma cell lines with AR expression negative. Biological characteristics of these cell lines make them be widely used in the research to study pathology and genetic stability of prostate cancer.