Example of an ethanolamine plasmalogen with the characteristic vinyl ether linkage at the sn-1 position and an ester linkage at the sn-2 position Plasmalogens are a class of glycerophospholipid with a plasmenyl group linked to a lipid at the sn-1 position of the glycerol backbone.

Restoring plasmalogen levels by use of plasmalogen replacement therapy has been shown to be a successful anti-inflammatory strategy as well as ameliorating several pathological hallmarks of these diseases.

As we age, particularly after the age of 50, or in the presence of inflammation, there is a notable decrease in plasmalogen levels. This decline is even more pronounced in individuals suffering from neurodegenerative conditions, where the reduction in plasmalogens occurs at a faster rate.

plasmalogen side chains are enriched in grey matter since they assist in signal transduction. Plasmalogens may act through multiple mechanisms. They are part of the plasma membrane, making it more fluid and thereby increasing cellular signaling and …

Plasmalogen modulation has been utilised in both preclinical and clinical studies to prevent onset and/or attenuate progression of neurodegenerative diseases, atherosclerosis, insulin resistance and hepatosteatosis.

Recent studies have revealed secondary plasmalogen deficiencies associated with more common disorders and allow us to tease out additional pathways dependent on plasmalogen functions. In this review, we present current knowledge of plasmalogen biology in health and disease.

Nov 4, 2024 · Research suggests interventions that improve plasmalogen availability to the body, specifically the nervous system, may help mitigate poor health outcomes like cognitive decline or brain atrophy. Not only that, but recent studies have suggested that plasmalogens enhance memory and reduce neuro-inflammation in the brain.

The research results establish that blood levels of structurally specific plasmalogen species can be preferentially targeted and modulated and that this is a therapeutically viable approach worthy of further investigation and optimization for the treatment of …

Plasmalogen is a specific glycerophospholipid present in both animal and bacterial organisms. It plays a crucial function in eukaryotic cellular processes and is closely related to several human diseases, including neurological disorders and ...

Plasmalogen is a phospholipid, a unique class of membrane structures that comprise an essential component of cellular health. It has anti-oxidative properties and is studied globally for its unique molecular structure and role in health.