Apr 4, 2025 · Protein design (or protein engineering) is a technique by which proteins with enhanced or novel functional properties are created.

Mar 21, 2025 · Protein design has evolved dramatically over the past 40 years from rational design to contemporary data-driven approaches. The field has now reached milestones such …

Proteins can be designed from scratch (de novo design) or by making calculated variants of a known protein structure and its sequence (termed protein redesign). Rational protein design …

Drawing inspiration from these natural marvels, we seek to design equally useful molecules from scratch. Our work is unlocking a new era of medical treatments and innovative materials, …

Protein design is the process of creating new proteins with specific properties by manipulating the sequence of amino acids. It involves a combination of computational techniques, laboratory …

Jul 11, 2023 · We demonstrate the power and generality of the method, called RoseTTAFold diffusion (RFdiffusion), by experimentally characterizing the structures and functions of …

A current goal in protein design is to create new methods to control protein activity in vivo. These methods would be a useful tool for studying processes that occur on fast timescales, as well …

Feb 1, 2024 · Methods from artificial intelligence (AI) trained on large datasets of sequences and structures can now “write” proteins with new shapes and molecular functions de novo, without …

The Huang lab specializes in designing new proteins and rewiring native ones. We use computational and experimental tools to study and use the principles of protein folding in our …

How well does protein design work? • Some impressive recent successes • However, one should keep in mind that: – Successful protein design projects often involve making and …