Secondary bile acids result from bacterial actions in the colon. In humans, taurocholic acid and glycocholic acid (derivatives of cholic acid ) and taurochenodeoxycholic acid and glycochenodeoxycholic acid (derivatives of chenodeoxycholic acid ) are the major bile salts.

Aug 29, 2023 · From there, there are a few different paths bile salts can take. Some bile salts stay unaltered and travel to the duodenum as primary bile salts. Others encounter intestinal bacteria...

Oct 27, 2020 · Secondary bile salts are produced through the action of bacteria in the intestines that transform primary bile salts into secondary bile salts through the removal of a hydroxyl group. Examples of this conversion are cholate becoming deoxycholate (DOC) and chenodeoxycholate becoming lithocholate.

May 1, 2023 · Secondary bile acids, e.g., deoxycholic acid, may have implications in more strongly downregulating bile acid synthesis than primary bile acids when it comes to negative feedback. The TGR5 receptor is involved in the regulation of energy homeostasis by bile acids.

Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial metabolites in the colon, cause opposing effects on colonic inflammation at chronically high physiological levels.

Secondary bile acids (BAs) are derived by bacterial manipulation of the primary BAs produced by the liver. This review summarizes the most important recent findings with regard to secondary BAs interaction with biliary epithelia.

The 7-deoxy bile acids are termed “secondary” bile acids because they are formed by bacterial enzymes, and thus should be distinguished from “primary” bile acids that are synthesized in the liver. Bile salts have a metabolism that differs from that of other biliary lipids.

Oct 18, 2024 · Secondary bile acids are diverse in structure and function, with each type playing distinct roles in the gut and beyond. Among the most studied are deoxycholic acid, lithocholic acid, and ursodeoxycholic acid, each contributing uniquely to gut health and metabolic processes.

Feb 19, 2025 · When the primary bile acids are excreted into the intestines they are acted upon by gut microbiota generating the secondary bile acids. In humans the secondary bile acid derived from CA is deoxycholic acid (DCA) and from CDCA is lithocholic acid (LCA).

Jan 15, 2025 · Bile salts, upon reaching the intestine, encounter a diverse microbial community that actively modifies their structure. This microbial transformation converts primary bile acids into secondary bile acids, such as deoxycholic acid and lithocholic acid.