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  1. About Smallpox | Smallpox | CDC - Centers for Disease Control …

    Oct 22, 2024 · Smallpox was an infectious disease caused by the variola virus. Smallpox has been eradicated, with no cases occurring since 1977. The disease caused rashes and could spread through coughing and sneezing. Smallpox no longer occurs naturally, but it is possible that variola virus could be used in a biological attack.

  2. Smallpox - Wikipedia

    Smallpox was an infectious disease caused by Variola virus (often called Smallpox virus), which belongs to the genus Orthopoxvirus.

  3. Smallpox - Symptoms and causes - Mayo Clinic

    Aug 5, 2022 · Smallpox is a serious and often deadly viral infection. It's contagious — meaning it spreads from person to person — and can cause permanent scarring. Sometimes, it causes disfigurement. Smallpox has affected humans for thousands of years but was wiped out worldwide by 1980 thanks to smallpox vaccines. It's no longer found naturally in the ...

  4. Smallpox - World Health Organization (WHO)

    Jun 20, 2024 · Smallpox is an acute contagious disease caused by the variola virus, a member of the orthopoxvirus family. It was one of the most devastating diseases known to humanity and caused millions of deaths before it was eradicated. It is …

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  5. Smallpox: Causes, Symptoms, Treatment & Prevention - Cleveland Clinic

    Smallpox was a serious illness caused by the variola virus. It caused a severe rash that often left disfiguring scars. About 1 in 3 people who got smallpox died. Smallpox has been eradicated since 1980. There haven’t been any cases since 1978. Smallpox was the first disease for …

  6. Smallpox - StatPearls - NCBI Bookshelf

    Aug 8, 2023 · Smallpox is the first human infectious disease to be successfully eradicated worldwide. It remains of clinical concern because of the potential for release and weaponization. Smallpox is a member of the viral family poxvirus, genus orthopoxvirus, and species variola virus.

  7. How Smallpox Spreads - CDC

    Oct 22, 2024 · Before smallpox was eradicated, it was mainly spread by direct and fairly prolonged face-to-face contact between people. The virus can spread through materials or objects contaminated by smallpox scabs and the fluid found in smallpox sores.

  8. Smallpox | Definition, History, Vaccine, & Facts | Britannica

    Mar 21, 2025 · smallpox, acute infectious disease that begins with a high fever, headache, and back pain and then proceeds to an eruption on the skin that leaves the face and limbs covered with cratered pockmarks, or pox.

  9. Smallpox: History, cause, vaccine, and does it still exist?

    Feb 28, 2022 · Smallpox was a severe infectious disease that affected humans for thousands of years before its eradication in the late 20th century. The symptoms included a distinctive rash, pustules, and...

  10. Smallpox - National Institute of Allergy and Infectious Diseases

    Smallpox, caused by the variola virus, was a highly contagious infectious disease that caused infected individuals to develop a fever and a progressive, disfiguring skin rash. Three of out 10 individuals infected with smallpox died.

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