Mar 24, 2023 · The spindle assembly checkpoint (SAC) ensures correct chromosome segregation during mitosis by inhibiting anaphase until all kinetochores are attached to microtubules.

Mar 28, 2023 · In this Review, we discuss key concepts in our understanding of spindle assembly, focusing on recent advances and the new approaches that enabled them.

Feb 8, 2017 · Three microtubule nucleation pathways function in mitotic cells to contribute microtubules to the assembling spindle, namely the centrosome-, chromatin- and microtubule …

Apr 29, 2025 · The spindle assembly checkpoint (SAC) prevents premature anaphase onset until all chromosomes are correctly attached to the mitotic spindle, reducing errors like aneuploidy, …

Nov 20, 2012 · During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be …

Here, we examine the evidence for the existence of a RanGTP gradient around mitotic chromosomes and some controversial data on the role that chromosomes play in spindle …

The spindle assembly checkpoint (SAC) ensures correct segregation by informing the cell cycle machinery of potential errors in the interactions of chromosomes with spindle microtubules …

Oct 19, 2015 · The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle.

The spindle assembly checkpoint controls cell cycle progression during mitosis, synchronizing it with the attachment of chromosomes to spindle microtubules. After the discovery of the mitotic …

A typical belt driven spindle assembly consists of the spindle shaft, held with a bearing system and supported by the spindle housing. The spindle shaft incorporates the tooling system, …