Nov 16, 2008 · Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by t (15;17) (q22;q21), a balanced reciprocal translocation involving PML and RARA genes.

The diagnostic translocation t(15;17) between chromosomes 15 and 17, which is responsible for the distinctive biology of APML, was definitively established in a seminal publication by Richard Larson, Janet Rowley and colleagues in 1984. 1 This manuscript brought together the meticulous characterization of the clinical, microscopic and ...

Feb 19, 2009 · Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t (15;17), resulting in the formation of the PML-RARA gene.

Acute promyelocytic leukemia is a subtype of acute myelogenous leukemia (AML), a cancer of the blood and bone marrow. It is also known as acute progranulocytic leukemia; APL; AML with t (15;17) (q22;q12), PML-RARA and variants; FAB subtype M3 and M3 variant. In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes.

Acute promyelocytic leukemia is characterized by a specific t(15;17) chromosomal translocation and a particular sensitivity to retinoic acid. The translocation fuses the PML gene to the retinoic acid receptor alpha (RAR alpha) gene resulting in the …

The diagnostic translocation t(15;17) between chromosomes 15 and 17, which is responsible for the distinctive biology of APML, was definitively established in a seminal publication by Richard Larson, Janet Rowley and colleagues in 1984. 1 This manuscript brought together the meticulous characterization of the clinical, microscopic and ...

May 1, 2006 · Almost always, a unique translocation [t(15;17)] leads to the production of a fusion oncoprotein made up of the first part of PML, an unrelated protein, and the last part of RARα (Figure 1A).

Dec 23, 2024 · Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the formation of the PML-RARA gene. Here, 47 t(15;17) APL samples were analyzed with high-density ...

Through these ka-ryotypic analyses, the authors identified a t(15;17) with identical breakpoints at 15q22 and 17q21.1 in every patient of their cohort (Figure 1A). They suggested that methodo-logical issues explained the previously reported uneven geographical distribution of …

We and others have shown that the t (15;17) translocation specifically associated with APL fuses an as yet unidentified gene, named PML, to the retinoic acid receptor alpha locus.