Nov 16, 2008 · Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by t (15;17) (q22;q21), a balanced reciprocal translocation …

The diagnostic translocation t(15;17) between chromosomes 15 and 17, which is responsible for the distinctive biology of APML, was definitively established in a seminal publication by …

Feb 19, 2009 · Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t (15;17), resulting in the formation of the PML …

Acute promyelocytic leukemia is a subtype of acute myelogenous leukemia (AML), a cancer of the blood and bone marrow. It is also known as acute progranulocytic leukemia; APL; AML with t …

Acute promyelocytic leukemia is characterized by a specific t(15;17) chromosomal translocation and a particular sensitivity to retinoic acid. The translocation fuses the PML gene to the …

The diagnostic translocation t(15;17) between chromosomes 15 and 17, which is responsible for the distinctive biology of APML, was definitively established in a seminal publication by …

May 1, 2006 · Almost always, a unique translocation [t(15;17)] leads to the production of a fusion oncoprotein made up of the first part of PML, an unrelated protein, and the last part of RARα …

Dec 23, 2024 · Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the formation of the PML …

Through these ka-ryotypic analyses, the authors identified a t(15;17) with identical breakpoints at 15q22 and 17q21.1 in every patient of their cohort (Figure 1A). They suggested that methodo …

We and others have shown that the t (15;17) translocation specifically associated with APL fuses an as yet unidentified gene, named PML, to the retinoic acid receptor alpha locus.