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T-2 mycotoxin - Wikipedia
T-2 mycotoxin is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of Fusarium spp. fungus which is toxic to humans and other animals. The clinical condition it causes is alimentary toxic aleukia and a host of symptoms related to …
T-2 mycotoxin: toxicological effects and decontamination strategies
The T-2 toxin caused reductions of succinate and citrate in urine and a reduced level of fumarate in the liver, accompanied by an increase in NAD at high levels in rats exposed to T-2, suggesting that T-2 lowers the rate of the tricarboxylic acid (TCA) cycle.
T-2 Toxin | C24H34O9 | CID 5284461 - PubChem
T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
T-2 and HT-2 Toxins: Toxicity, Occurrence and Analysis: A Review
T-2 toxin and its metabolite HT-2 toxin are detrimental to the health of animals and humans alike. These toxins are potent inhibitors of protein synthesis. Moreover, they are immunosuppressive and dermatotoxic, causing necrosis and haemorrhage of the intestinal mucosa.
An update on T2-toxins: metabolism, immunotoxicity mechanism …
In recent studies, immunotoxicity mechanism of T-2 toxin and human T-2 toxin is discussed. In general terms, the microbiota have potential benefit on mycotoxins toxicity, an adverse finding in the form of conjugated/masked mycotoxins hydrolysis was recently discovered.
T 2 Toxin - an overview | ScienceDirect Topics
T-2 Toxin. T-2 toxin is produced primarily by F. sporotrichioides and has been reported in many areas of the world. It is formed in large quantities in the unusual circumstance of prolonged wet weather at harvest.
T-2 toxin, a trichothecene mycotoxin: review of toxicity
Apr 27, 2011 · Among the naturally occurring trichothecenes in food and feed, T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. Following ingestion, T-2 toxin causes acute and chronic toxicity and induces apoptosis in the immune system and fetal tissues.
An update on T-2 toxin and its modified forms: metabolism
Modified forms of T-2 toxin, including T-2-3-glucoside, exert their immunotoxic effects by signaling through JAK/STAT but not MAPK. T-2-3-glucoside results from hydrolyzation of the corresponding parent mycotoxin and other metabolites by the intestinal microbiota, which leads to …
An update on T2-toxins: metabolism, immunotoxicity
Aug 1, 2022 · T-2 toxin is simply one of the metabolites belonging to fungi trichothecene mycotoxin. Specifically, Trichothecenes-2 (T-2) mycotoxin of genus fusarium is considered one of the most hotspot agricultural commodities and carcinogenic compounds worldwide.
Overview of T-2 Toxin Enterotoxicity: From Toxic Mechanisms and ...
Feb 21, 2024 · Fusarium species produce a secondary metabolite known as T-2 toxin, which is the primary and most harmful toxin found in type A trichothecenes. T-2 toxin is widely found in food and grain-based animal feed and endangers the health of both humans and animals.