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Thymocyte - Wikipedia
Thymocytes are produced as stem cells in the bone marrow and reach the thymus via the blood. Thymopoiesis describes the process which turns thymocytes into mature T cells according to either negative or positive selection.
Thymus development and function - PubMed
Thymopoiesis is a complex and highly dynamic process. It involves reciprocal tissue interactions between epithelial cells derived from the endoderm of the anterior foregut and neural crest-derived mesenchyme to form the thymic rudiment.
Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell ...
Jan 31, 2020 · We have revealed that mTORC1/Raptor signaling in TECs is crucial for thymopoiesis. Proper generation of multiple T cell lineages, including Tregs, iNKT cells, γδT17 differentiation, as well as TCRVγ5/6Vδ1 recombination, …
Reading the Ts and DCs of thymopoiesis - Nature Immunology
Feb 24, 2023 · Thymopoiesis is the best-studied example of the fact that hematopoiesis does not end at the boundary of the sinusoidal endothelium in the bone marrow.
Thymic Extracellular Matrix in the Thymopoiesis: Just a Supporting?
Thymopoiesis consists of a continuous production of naïve self-tolerant T cells by the thymus to ensure an immune response against antigens and homeostasis in the peripheral tissues. In this process, T cell progenitors arise in the bone marrow from hematopoietic stem cells.
Thymopoiesis in 4 dimensions - ScienceDirect
Feb 1, 2005 · Thymopoiesis involves the tightly regulated movement of cells over considerable distances to achieve the final production of mature T cells. In this review we focus on what is known, and not known, of the spatial organization within the thymus, how thymic compartmentalization is maintained, and how cell movement proceeds across the thymic ...
Cell Competition, the Kinetics of Thymopoiesis, and Thymus
Jul 21, 2020 · We aimed to understand the effect of cell competition on thymopoiesis, identify the cells involved, and determine how the process is regulated. Using thymus transplantation experiments, we found that cell competition occurs within the double-negative 2 (DN2) and 3 early (DN3e) thymocytes and inhibits thymus autonomy.
Blueprint of human thymopoiesis reveals molecular mechanisms …
Sep 9, 2020 · Here we present a comprehensive resource of epigenomic data of human T cell precursors along with an integrative analysis of other hematopoietic populations.
Insufficient recovery of thymopoiesis predicts for opportunistic ...
The predictive impact of insufficient thymopoiesis was assessed and quantified: patients with failed recovery of thymopoiesis had 3- and 9-fold higher risks for severe infections and non-relapse mortality beyond the 6- and 12-month time points, respectively.
Evolution of Genetic Networks Underlying the Emergence of Thymopoiesis ...
Jul 10, 2009 · We set out to reconstruct the evolutionary origins of thymopoiesis, employing the following strategy. First, we analyzed the genomes of several key chordate and vertebrate species in order to trace the evolutionary history of genes potentially involved in …