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In UniProtKB/Swiss-Prot, we annotate transmembrane regions, when: the transmembrane regions have been experimentally determined; there is some experimental evidence for the number, …
AFTM: a database of transmembrane regions in the human …
Mar 14, 2023 · We developed the AlphaFold Transmembrane proteins (AFTM) database of candidate human TMPs by identifying transmembrane regions in AlphaFold structural models …
Transmembrane Domain - an overview | ScienceDirect Topics
The transmembrane domain consists of a hydrophobic α helix that spans the cell membrane and is probably the least characterized region of the CAR. Although the main function of the …
De novo-designed transmembrane proteins bind and regulate a …
Mar 13, 2024 · Transmembrane (TM) domains as simple as a single span can perform complex biological functions using entirely lipid-embedded chemical features. Computational design …
11.1: Membranes and Membrane Proteins - Biology LibreTexts
Proteins can be loosely associated with the membrane (peripheral or extrinsic), embed deeply, or pass through the membrane and become a transmembrane (also called i ntegral or intrinsic) …
Characterization of Five Transmembrane Proteins: With Focus on …
Transmembrane (TM) proteins are involved in many crucial cell processes including receptor and signaling transduction pathways, transport of ions and molecules across impermeable …
Transmembrane proteins - Abcam
Transmembrane proteins traverse the lipid bilayer of cell membranes, with segments exposed to both extracellular and intracellular environments. These proteins are typically composed of α …
Hinge and Transmembrane Domains of Chimeric Antigen …
May 9, 2020 · To clarify the role of hinge and transmembrane domains in CAR and CAR-T cell function, we generated different chimeras and analyzed their expression levels and antigen …
Transmembrane Protein - an overview | ScienceDirect Topics
A transmembrane protein refers to a type of protein that is found in both prokaryotic and eukaryotic organisms and is involved in important biological processes.
The architecture of transmembrane and cytoplasmic juxtamembrane regions ...
Mar 17, 2023 · Here we use solution NMR spectroscopy and computer simulations to investigate the spatial structures of transmembrane and cytoplasmic juxtamembrane regions of TLR2, …
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