Jul 2, 2014 · Understanding tumor heterogeneity may be the next big quest in cancer science, as differences between cells within a tumor can have important consequences for how cancers …

Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, …

A term that describes the differences between tumors of the same type in different patients, the differences between cancer cells within a single tumor, or the differences between a primary …

Feb 15, 2021 · We will discuss how tumor heterogeneity causes resistance to various treatments and review the strategies currently being employed to overcome this challenging clinical …

Mar 18, 2025 · In this review, we discuss recent evidence concerning global perturbations of intratumoral heterogeneity, associations of specific intratumoral heterogeneity in lung cancer, …

Nov 25, 2014 · In this review, we seek to summarize major milestones in tumor evolution, identify key aspects of tumor heterogeneity in a TME-dependent evolutionary context, and provide …

Apr 28, 2023 · We review the role of the main models and the emerging single-cell and spatial genomic technologies in our understanding of tumor heterogeneity, its contribution to lethal …

Jan 8, 2024 · Emerging knowledge shows that drivers of tumor heterogeneity are not only intrinsic to cancer cells but can also emanate from their microenvironment, which significantly favors …

Dec 9, 2024 · Tumorigenesis is a heterogenous process, promoted not only by genetic mutations within cells, but also by the outer tissue space feeding the mutated cells - tumor …

Jan 28, 2025 · The clinical heterogeneity of cancer, which leads to differential treatment outcomes between patients with histopathologically similar cancers, is attributable to molecular diversity …