Urate oxidase - Wikipedia
The enzyme urate oxidase (UO), uricase or factor-independent urate hydroxylase, absent in humans, catalyzes the oxidation of uric acid to 5-hydroxyisourate: [4] sequence of oxidation of ureate. Urate oxidase is mainly localised in the liver, where it forms a large electron-dense paracrystalline core in many peroxisomes. [5] .
Management of Gout: Update from the American College of …
Allopurinol is the first-line urate-lowering therapy. Febuxostat (Uloric), the other xanthine oxidase inhibitor, is limited by increased cardiovascular and all-cause mortality seen in studies....
Urate Oxidase - an overview | ScienceDirect Topics
Urate oxidase is an enzyme that is contraindicated in individuals with glucose-6-phosphate dehydrogenase deficiencies due to their inability to metabolize hydrogen peroxide produced during the urate oxidase reaction. You might find these chapters and articles relevant to this topic.
Urate Oxidase - an overview | ScienceDirect Topics
Urate oxidase (uricase, EC 1.7.3.3) converts uric acid to 5-hydroxyisourate and H 2 O 2, leading to the formation of water-soluble allantoin, which is then readily excreted by the kidneys. Therefore uricase can be used to treat diseases such as gout, hyperuricemia, and osteoporosis.
Urate oxidase: primary structure and evolutionary implications
Urate oxidase, or uricase (EC 1.7.3.3), is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most mammals. In humans and certain other primates, however, the enzyme has been lost by some unknown mechanism.
Urate Oxidase - an overview | ScienceDirect Topics
Urate oxidase is an enzyme (not found in humans) that converts uric acid to allantoin, which is 5 to 10 times more water soluble than uric acid. You might find these chapters and articles relevant to this topic. Urate oxidase catalyzes the formation of 5-hydroxyisourate from urate.
Physiological functions and pathogenic potential of uric acid: A …
Humans cannot oxidize uric acid to the more soluble compound allantoin due to the lack of uricase enzyme. The enzyme uricase (urate oxidase) can metabolize uric acid to highly soluble 5-hydroxyisourate that is further degraded to allantoic acid and ammonia, easily excreted by …
Enhancing the Response Rate to Recombinant Uricases in Patients …
Uricase, also known as urate oxidase, is an enzyme that catalyzes the degradation of uric acid to 5-hydroxyisourate and allantoin, both of which are readily excreted from the body [1].
The Neutron Structure of Urate Oxidase Resolves a Long …
Jan 23, 2014 · Urate oxidase (Uox, EC 1.7.3.3) or uricase is an enzyme involved in the metabolism of purines. It catalyses the oxidation of uric acid to metastable 5-hydroxyisourate (5-HIU) which is further degraded to allantoin ( Fig. 1) either non-enzymatically [1] or with the assistance of two enzymes [2].
Mechanisms and rationale for uricase use in patients with gout
Sep 8, 2023 · In species other than humans, uricase (urate oxidase) converts urate to allantoin, which is more soluble in urine than uric acid. Exogenic uricases are an exciting therapeutic option for...