The Pemberton's sign is a physical examination tool used to demonstrate the presence of latent pressure in the thoracic inlet. [1] The sign is named after Hugh Pemberton, who characterized it in 1946. [2]

First described 60 years ago, 1 Pemberton sign occurs when the thoracic inlet becomes obstructed during positional changes, resulting in compression of the jugular veins. It is a common manifestation of retrosternal goiter but may also occur with lung carcinoma, lymphoma, thymoma, or aortic aneurysms.

Pemberton's Sign is a clinical marker used in the detection of thoracic outlet syndrome, specifically in cases of superior vena cava obstruction. First observed and described by the renowned physician Hugh Pemberton in 1946, this sign has since become a diagnostic cornerstone in identifying venous compression in the superior thoracic aperture.

Jun 1, 2014 · Pemberton's sign is used to evaluate venous obstruction in patients with goiters. The sign is positive when bilateral arm elevation causes facial plethora. It has been attributed to a “cork effect” resulting from the thyroid obstructing the thoracic inlet, thereby increasing pressure on the venous system.

Context: Pemberton's sign is used to evaluate venous obstruction in patients with goiters. The sign is positive when bilateral arm elevation causes facial plethora. It has been attributed to a "cork effect" resulting from the thyroid obstructing the thoracic inlet, thereby increasing pressure on the venous system.

Context: Pemberton's sign is used to evaluate venous obstruction in patients with goiters. The sign is positive when bilateral arm elevation causes facial plethora. It has been attributed to a "cork effect" resulting from the thyroid obstructing the thoracic inlet, thereby increasing pressure on the venous system.

Jul 9, 2024 · Clinicians observe for signs such as facial flushing, jugular vein distension, and respiratory distress. These manifestations may indicate superior vena cava compression by an enlarged thyroid gland, prompting further investigation of thyroid function and structure.

Aug 30, 2023 · Pemberton’s sign. The Pemberton manoeuvre may worsen these signs and symptoms. The patient should lift both arms until they touch the side of the face. A positive Pemberton’s sign is the presence of facial congestion, cyanosis and respiratory distress after ~1 …

Mar 25, 2004 · A 58-year-old woman with a 20-year history of goiter presented with a two-month history of progressive dyspnea on exertion, occasional stridor, and a choking sensation while supine. She had...

Feb 18, 2025 · Pemberton's Sign is a simple yet powerful test that helps doctors diagnose thyroid issues and other serious conditions by observing facial congestion when patients raise their arms. It's quick, non-invasive, and guides further testing for accurate diagnosis.