The Role of c-MYC in B-Cell Lymphomas: Diagnostic and …
In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on prognosis and …
The Role of c-MYC in B-Cell Lymphomas: Diagnostic and ... - PubMed
Apr 5, 2017 · In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on …
Understanding MYC-driven aggressive B-cell lymphomas: …
Dec 5, 2013 · MYC is a potent oncogene initially identified as the target of the t (8;14) (q24;q32) chromosome translocation in Burkitt lymphoma. MYC gene alterations have been identified in …
Targeting MYC-driven lymphoma: lessons learned and future …
MYC plays a central role in tumorigenesis by orchestrating cell proliferation, growth and survival, among other transformation mechanisms. In particular, MYC has often been associated with …
C-MYC Rearrangements are Frequent in Aggressive Mature B-Cell Lymphoma …
Although the number of patients is small, it appears that patients with aggressive mature B-cell lymphoma with atypical morphology and C-MYC rearrange-ments have benefited from the …
Approach to the diagnosis and treatment of high-grade B-cell …
Jan 19, 2017 · High-grade B-cell lymphomas (HGBLs) with MYC and BCL2 and/or BCL6 rearrangements, so-called “double-hit” lymphomas (HGBL-DH), are aggressive lymphomas …
Pathology Outlines - MYC
Jun 11, 2024 · Burkitt’s lymphoma: 90% have translocation of c-myc or variants; translocation causes continuous stimulation by adjacent enhancer element of immunoglobulin gene or …
The Role of c-MYC in B-Cell Lymphomas: Diagnostic and …
In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on prognosis and …
Epigenetics, c-Myc and Aggressive B-cell Lymphomas
Nov 13, 2012 · c-Myc plays a central role in aggressive B-cell lymphoma pathogenesis. c-Myc and c-Myc target miRNAs are regulated through histone modifications and can be …
c-Myc hot spot mutations in lymphomas result in inefficient ...
Mar 15, 2000 · Our results show that proteasome-mediated turnover of c-Myc is substantially impaired in Burkitt's lymphoma cells with mutated Thr58 or other mutations that abolish Thr58 …
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