Table of Substrates, Inhibitors and Inducers
Index inhibitors listed in this table were selected based on potency and selectivity of inhibition, safety profiles, and an adequate number of reported clinical DDI studies with different in vivo...
See results only from fda.govFor Healthcare Professionals
For example, if you are searching for strong 2C19 inhibitors (use the CYP strong …
Cytochrome P-450 CYP2D6 Inhibitors (strong) - DrugBank Online
188 rows · A selective serotonin reuptake inhibitor used to treat major depressive disorder, …
Long List of Inhibitors and Inducers of CYP3A4 and CYP2D6
Click to view a list of drugs the may induce or inhibit CYP3A4 or CYP2D6 enzymes in the body while on Gleevec. For a full list, visit The Life Raft Group.
- Estimated Reading Time: 1 min
CYP2D6 - Wikipedia
Following is a table of selected substrates, inducers and inhibitors of CYP2D6. Where classes of agents are listed, there may be exceptions within the class.
Inhibitors of CYP2D6 can be classified by their potency, such as:
• Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP2D6, or more than 80% decrease in clearance ther…Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 8 mins
For Healthcare Professionals | FDA’s Examples of Drugs that …
Jun 24, 2024 · For example, if you are searching for strong 2C19 inhibitors (use the CYP strong inhibitor filter and select “2C19” in the drop-down menu) and weak CYP 2B6 …
List of Drugs That Inhibit CYP2D6 - Med Ed 101
Nov 30, 2022 · In this article I highlight my list of drugs that inhibit CYP2D6 and also share some case examples from my clinical pharmacy practice.
At the time that this document was written, this link contained three tables that stratify pharmacogenetic associations according to those supported by data for therapeutic …
Cytochrome P-450 CYP2D6 Inhibitors (moderate) - DrugBank Online
For the management of severe angina pectoris. A beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. A tricyclic …
A strong inhibitor is one that caused a ≥ 5-fold increase in the plasma AUC values or more than 80% decrease in clearance of CYP3A substrates (not limited to midazolam, a sensitive CYP3A …
A Scoping Review of the Evidence Behind Cytochrome P450 2D6
The US Food and Drug Administration (FDA) lists 22 medications as clinical inhibitors of cytochrome P450 2D6 isoenzyme, with classifications of strong, moderate, and weak. It is …
