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Achondroplasia is an autosomal dominant disorder characterized by disproportionate short stature: the legs and arms are short compared with the head and trunk. The disorder is due to a base substitution in the gene, located on the short arm of chromosome 4, for fibroblast growth factor receptor 3 (FGFR3). Although a chondroplasia is clearly inherited as an autosomal dominant trait, more than 80 % of the people who have achondroplasia are born to parents with normal stature. This high percentage
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